Kappa-opioid receptor signaling in the striatum as a potential modulator of dopamine transmission in copyright dependence

Kappa-opioid receptor signaling in the striatum as a potential modulator of dopamine transmission in copyright dependence

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copyright addiction is accompanied Cardamon by a decrease in striatal dopamine signaling, measured as a decrease in dopamine D2 receptor binding as well as blunted dopamine release in the striatum.These alterations in dopamine transmission have clinical relevance, and have been shown to correlate with copyright-seeking behavior and response to treatment for copyright dependence.However, the mechanisms contributing to the hypodopaminergic state in copyright addiction remain unknown.Here we review the Positron Emission Tomography (PET) imaging studies showing alterations in D2 receptor binding potential and dopamine transmission in copyright abusers and 70s Slingback Clog their significance in copyright-seeking behavior.

Based on animal and human studies, we propose that the kappa receptor/dynorphin system, because of its impact on dopamine transmission and upregulation following copyright exposure, could contribute to the hypodopaminergic state reported in copyright addiction, and could thus be a relevant target for treatment development.